Pharmacy compounding is the art and science of preparing customized medications for patients. The advantage of compounded HRT is that it can be adapted specifically to fit each individual’s body and hormone levels. HRT can utilize hormones that have the exact chemical structure as the hormones in the human body. The body recognizes them and allows them to mimic the function of the hormones the body produces on its own.

Unbalanced hormones can make you feel like a stranger in your own skin.

Anyone who has been through puberty knows that hormones have a powerful effect on one’s body. Hormones affect many areas of your health, including your mood, your metabolism, and your sexual and reproductive function. If your hormones become unbalanced, whether due to menopause or other factors, you may end up feeling like a stranger in your own skin. However, compounded hormone replacement therapy (HRT) is a way to restore balance and help you feel like yourself again.



Natural Transdermal Progesterone Cream

Your prescriber has ordered you transdermal progesterone cream.  Progesterone is a steroid hormone made by the corpus luteum of the ovary at ovulation, and in smaller amounts by the adrenal glands.   Community Pharmacy Compounding and Wellness Center uses only PCCA Special Micronized Progesterone when compounding natural transdermal progesterone cream.  Progesterone USP, Special Micronized from PCCA, comes from the finest chemicals and is a pharmacopoeial grade hormone powder that consistently meets potency standards. USP progesterone used for hormone replacement comes a substance called diosgenin which is extracted from the plant fats and oils of a very specific type of wild yam that grows in Mexico or from soybeans. In the laboratory diosgenin is chemically synthesized into real human progesterone.  Some companies are trying to sell diosgenin  which they label "wild yam extract" as a medicine or supplement  claiming that the body will then convert it into hormones as needed. While we know this can be done in the laboratory, there is no evidence that this conversion takes place in the human body.



Where should Transdermal Progesterone Cream be applied?


Your transdermal progesterone cream should be applied as directed by your prescriber.


Your cream will be dispensed in either a mega pump device or a device called an EMP jar with a syringe.  Please see the additional inserts for proper use of the appropriate device


If your prescriber has not given you specific instructions on where and how to apply the natural progesterone cream,  we suggest applying to thin skin areas (areas where you blush). Apply to alternating thin skin areas such as inner arms, behind the knees, chest, breasts, neck, torso, upper back - you may even want to put it on wrinkles under the eye and around the mouth. It is important to rotate sites because of pooling of the hormone that prevents even absorption.  If you apply the natural progesterone cream to the same sites every day, you will get a buildup of hormone in this area of your skin.  This build up will interfere with the absorption of your progesterone cream.

An alternate place for application would be to your mucous epithelial membranes that line your uterus and vagina. Not only is absorption through these membranes more complete than through your skin, but hormones absorbed through your vaginal membranes enter the very same pelvic plexus of veins that your ovaries normally empty into. From here the hormones are carried to your heart and lungs and distributed to your tissues just as if your ovary had actually produced them.

How should your transdermal progesterone cream be used?


You should use your transdermal progesterone cream as directed by your prescriber.


Current recommendations for use will depend on your current hormonal and menstrual status.

  • Women in their reproductive years - still ovulating. In this case, women would normally use transdermal progesterone cream  for PMS, painful cramping with periods, menstrual irregularities. 
    • Begin using the cream after you have ovulated - about 10 to 12 days after your period begins. Count the day the period begins as the first day.
    • Apply the prescribed amount of cream every day from day 12 to day 26.
  • Women who are post menopausal. Use a calendar day (e.g. the first day of the month) as day one. 
    • Days 1 to 12 apply the prescribed amount of cream daily.
    • Days 12 to 25, apply the prescribed amount of cream once or twice a day as directed
    • Days 26 to 30 or 31? NONE. 

NOTE: For men, we suggest applying the prescribed amount daily, 6 days a week.


Do I need a break from using the cream each month? Yes. For menstruating women it is common for the progesterone cream to be used from the 12th to the 26th day, counting the day the period starts as the first day. For non-menstruating or menopausal women, when using a calendar, stop after day 26 and start again on the first of the next month - again, mimicking your body's natural rhythm.

If you see menstrualbleeding, you should STOP the cream and start counting again

that day as day 1 of your cycle.  Restart your cream on the proper day of your cycle as directed.


Side Effects:

If used properly, transdermal progesterone cream rarely has any side effects   Some possible side effectsmay include drowsiness, nausea, headaches, and breast pain.   

Please Note:  Transdermal progesterone cream may theoretically reduce the effectiveness of oral contraceptive pills ( i.e. birth control pills.)  Please consider using a back up birth control method if this applies to you.


Additional information

PLEASE NOTE:  A lack of vitamin D reduces the benefits of progesterone. We suggest taking a high quality vitamin D supplement ranging from 1000iu to 5000iu daily. We suggest asking your prescriber to have a test done to confirm your levels.

PLEASE NOTE: If you are using skin care moisturizers and lotions that contain petroleum or mineral oil, this can reduce the effectiveness of natural progesterone cream. Please find a healthy skin care or moisturizer without the harmful petroleum products.  Please visit to look at the high quality pharmaceutical grade skin care products sold by Community Pharmacy Compounding and Wellness Center.  For more information or a sample, call us at 814-684-0230.



How to use Cream in EMP:

Step 1: Take the syringe and separate it into 2 parts. You will now have the white, blue or other color plunger part and the main barrel part of the syringe with markings on it.

Step 2: The jar of cream has a movable base, which can be pushed up to expel air out of the jar. It also has 2 lids, one small and one larger lid.   Undo the smaller of the 2 lids. You will see a small pink insert in the top. DO NOT remove this. It is important to keep it in place to fill the syringe.

Step 3: Gently push the movable base upwards, so that you can see the cream appear level with the pink insert. This will ensure there is no air in the jar and will make filling the syringe easier.

Step 4: Now, take the barrel part of the syringe with number markings and insert it into the top of the pink opening.  It may be a little tight at first, but will push down snugly with slight force.

Step 5: Now, push the movable base upwards slowly. You will notice the cream filling in the syringe. Slightly overfill the syringe (eg if you require a One ml dose, fill a little past that) then, insert the white plunger, while the barrel syringe is still in the pink opening.

Step 6: Finally, push the white plunger insert back into the barrel of the syringe push the cream to the exact measurement required and remove the whole unit from the pink adapter.